Timothy T. Spear

机构：Children's Hospital of Philadelphia · ORCID：0000-0001-7740-5119

发表论文 41 篇 · 总被引 645 次 · h-index 14

代表论文

Atomically accurate de novo design of antibodies with RFdiffusion (2025 · Nature · 被引 103)
Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy (2019 · Cancer Immunology Immunotherapy · 被引 62)
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma (2024 · Nature Communications · 被引 33)
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus (2024 · Journal for ImmunoTherapy of Cancer · 被引 14)
Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells (2018 · Molecular Therapy · 被引 14)
Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells (2025 · Molecular Therapy · 被引 12)