Makoto Hirasawa

机构：Leiden University, Centre for Human Drug Research · ORCID：0000-0002-1678-8539

发表论文 21 篇 · 总被引 360 次 · h-index 10

代表论文

• Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor (2017 · Cancer Science · 被引 143)
• RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer (2019 · Cell chemical biology · 被引 72)
• Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion (2022 · Cancer Research · 被引 32)
• Synthesis and evaluation of (−)- and (+)-[11C]galanthamine as PET tracers for cerebral acetylcholinesterase imaging (2013 · Bioorganic & Medicinal Chemistry · 被引 16)
• Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model (2022 · Pharmaceutics · 被引 15)
• Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity (2020 · ACS Medicinal Chemistry Letters · 被引 13)