Noriko Uchiyama

机构：Takeda (Japan) · ORCID：0000-0003-4042-1574

发表论文 71 篇 · 总被引 1323 次 · h-index 18

代表论文

• CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor (2017 · Nature Communications · 被引 140)
• Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives (2013 · Journal of Medicinal Chemistry · 被引 113)
• Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor (2019 · Science Advances · 被引 70)
• Discovery of 3-Benzyl-1-( trans -4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors (2018 · Journal of Medicinal Chemistry · 被引 65)
• Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders (2017 · Journal of Medicinal Chemistry · 被引 37)
• Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase (2020 · Journal of Medicinal Chemistry · 被引 32)