Mitchell D. Nambu

机构：Institute of Medicinal Plant Development

发表论文 12 篇 · 总被引 1891 次 · h-index 6

代表论文

• Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK) (2011 · Journal of Medicinal Chemistry · 被引 928)
• An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms (2007 · Cancer Research · 被引 757)
• Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazin-6-yl)-1 H -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer (2012 · Journal of Medicinal Chemistry · 被引 105)
• Lessons from (S)-6-(1-(6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an Inhibitor of Receptor Tyrosine Kinase c-Met with High Protein Kinase Selectivity but Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats (2013 · Journal of Medicinal Chemistry · 被引 39)
• 4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors (2010 · Bioorganic & Medicinal Chemistry Letters · 被引 33)
• A calcineurin antifungal strategy with analogs of FK506 (2017 · Bioorganic & Medicinal Chemistry Letters · 被引 27)