Elizabeth Heimrich

机构：Bristol-Myers Squibb (United States) · ORCID：0000-0001-5854-1342

发表论文 23 篇 · 总被引 1232 次 · h-index 11

代表论文

• Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 (2019 · Journal of Medicinal Chemistry · 被引 381)
• Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain (2019 · Science Translational Medicine · 被引 292)
• Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers (2016 · Journal of Medicinal Chemistry · 被引 147)
• Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK) (2019 · Journal of Medicinal Chemistry · 被引 113)
• Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2) (2019 · Journal of Medicinal Chemistry · 被引 95)
• Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care (2017 · PLoS ONE · 被引 58)