Patricia C. Salinas

机构：MRC Laboratory for Molecular Cell Biology, University College London · ORCID：0000-0002-5748-083X

发表论文 130 篇 · 总被引 9455 次 · h-index 47

代表论文

• A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease (2023 · Science Advances · 被引 37)
• Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters (2022 · Molecular Psychiatry · 被引 37)
• Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model (2023 · eLife · 被引 17)
• Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit (2022 · Journal of Medicinal Chemistry · 被引 17)
• Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model (2024 · eLife · 被引 14)
• Microglial Expression of the Wnt Signaling ModulatorDKK2Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models (2023 · eNeuro · 被引 13)