Semantha Ellis

机构：MSD (UK) Limited (United Kingdom)

发表论文 11 篇 · 总被引 359 次 · h-index 8

代表论文

• Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide] (2005 · Journal of Pharmacology and Experimental Therapeutics · 被引 99)
• The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse (2006 · Journal of Pharmacology and Experimental Therapeutics · 被引 86)
• The non‐peptidyl fungal metabolite L‐783,281 activates TRK neurotrophin receptors (2001 · Journal of Neurochemistry · 被引 49)
• Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity (2004 · Journal of Biological Chemistry · 被引 38)
• Intra- or Intercomplex Binding to the γ-Secretase Enzyme (2006 · Journal of Biological Chemistry · 被引 37)
• The Staurosporine-Like Compound L-753,000 (NB-506) Potentiates the Neurotrophic Effects of Neurotrophin-3 by Acting Selectively at the TrkA Receptor (1999 · Molecular Pharmacology · 被引 29)