Alexei Brooun

机构：Itasca Consultants (United States)

发表论文 101 篇 · 总被引 6111 次 · h-index 28

代表论文

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation (2021 · Nature Communications · 被引 125)
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195) (2020 · Journal of Medicinal Chemistry · 被引 40)
Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors (2023 · ACS Medicinal Chemistry Letters · 被引 17)
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels (2023 · Proceedings of the National Academy of Sciences · 被引 14)
Abstract 390: ERAS-0015 is a pan-RAS molecular glue with best-in-class potential in RAS mutant solid tumors (2025 · Cancer Research · 被引 4)
The pharmacologic and toxicologic characterization of the potent and selective KRAS G12D inhibitors ERAS-4693 and ERAS-5024 (2023 · Toxicology and Applied Pharmacology · 被引 4)