Benjamin J. Burke

发表论文 42 篇 · 总被引 2155 次 · h-index 15

代表论文

• Discovery of (10 R )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- 2H -8,4-(metheno)pyrazolo[4,3- h ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations (2014 · Journal of Medicinal Chemistry · 被引 593)
• Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F (2015 · New England Journal of Medicine · 被引 488)
• Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer (2018 · Cancer Discovery · 被引 316)
• 1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho / meta -substituted arenes (2021 · Proceedings of the National Academy of Sciences · 被引 122)
• Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib (2014 · Journal of Medicinal Chemistry · 被引 118)
• Characterization of Specific N -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library (2020 · ACS Medicinal Chemistry Letters · 被引 35)